Quinolines and derivatives

Aromatic organic heterocyclic compounds that contain a benzene ring fused with a six-membered ring that contains one nitrogen atom and five carbon atoms. Includes compounds that are derived from quinolines.

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3,421 – 3,435 of 3,763 results

3,421

Medchemexpress LLC Revumenib | 2169919-21-3 | 99.99% | 630.82 | 200 MG

Revumenib (SNDX-5613) is a potent and specific Menin-MLL inhibitor with a binding Ki of 0.149 nM and a cell-based IC50 of 10-20 nM. It is intended for the research of MLL-rearranged (MLL-r) acute leukemias, including acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). For research use only; not for sale to patients.

Potent and specific Menin-MLL inhibitor.
Applicable for research in MLL-rearranged acute leukemias (ALL and AML).
Shows in vivo plasma IC50 of 53 nM.
Provides significant survival benefit and leukemic control in aggressive MOLM-13 disseminated xenografts in vivo.

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3,422

Ambeed Methyl 4bromo3methylbenzoate

Methyl 4-bromo-3-methylbenzoate, 148547-19-7, 98%

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3,423

eMolecules 4-Chloro-8-methoxy-quinoline | 16778-21-5 | MFCD00033679 | 25g

J & W PharmLab LLC | 4-Chloro-8-methoxy-quinoline | 25g | 452547681 | 80R0178 | 97.000 | 16778-21-5 | MFCD00033679 | 193.630 | C10H8ClNO

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3,424

Medchemexpress LLC Peg-bis-amine (MW 2000) | 24991-53-5 | 99.4% | (C2H4O)nC4H12N2O | 250 MG

PEG-bis-amine (Poly(ethylene glycol)-bis-amine) (MW 2000) is a PEG-based PROTAC linker. It is used in the synthesis of PROTACs, which are molecules designed to exploit the intracellular ubiquitin-proteasome system for selective degradation of target proteins.

Can be used in the synthesis of PROTACs
PROTACs contain two different ligands connected by a linker
Ligands are for an E3 ubiquitin ligase and a target protein
PROTACs exploit the intracellular ubiquitin-proteasome system
Selectively degrades target proteins

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3,425

Medchemexpress LLC M-PEG12-AMINE 10MG

5000202629 M-PEG12-AMINE 10MG

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3,426

Medchemexpress LLC MPEG-amine (MW 20000) | 80506-64-5 | 98.0% | (C2H4O)nC3H9NO | 250 MG

MPEG-amine (MW 20000) is a PEG-based PROTAC linker, crucial for the synthesis of PROTACs. These PROTACs are innovative molecules that utilize the intracellular ubiquitin-proteasome system to selectively degrade target proteins, featuring two distinct ligands connected by a linker: one targeting an E3 ubiquitin ligase and the other for the target protein.

PEG-based PROTAC linker
Used in the synthesis of PROTACs
Exploits ubiquitin-proteasome system to degrade target proteins
Average molecular weight of 20000
Appears as a solid
Color is white to off-white

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3,427

Medchemexpress LLC 2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-amine | 211859-73-3 | MFCD16619283 | 97.0% | 427.53 | C19H41NO9 | 250 MG

m-PEG9-Amine is a methoxy-terminated polyethylene glycol linker bearing a terminal primary amine used in synthesis workflows for antibody-drug conjugates and PROTAC molecules.

Used as a cleavable ADC linker and as a PEG-based PROTAC linker.
Molecular formula C19H41NO9 and molecular weight 427.53.
Chemical name: 2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-amine.
Purity typically 97.0% by NMR (per COA).
Store dissolved in solvent at -80°C (6 months) or -20°C (1 month); protect from light.

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3,428

Apexbio Technology LLC APEXBIO TECHNOLOGY LLC

5000570030 TIPIRACIL-200MG

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3,429

Ambeed Pyrazine2carbaldehyde

Pyrazine-2-carbaldehyde, 5780-66-5, 95%

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3,430

Medchemexpress LLC Ethanamine, 2-(2-methoxyethoxy)- | 31576-51-9 | 99.9% | 119.16 | C5H13NO2 | 500 MG

m-PEG2-Amine is a methoxy-terminated polyethylene glycol (PEG) linker that provides a short PEG2 spacer with a terminal primary amine for conjugation. It is used as a cleavable linker in antibody-drug conjugate (ADC) synthesis and as a PEG-based linker in proteolysis-targeting chimera (PROTAC) construction.

Short PEG spacer with terminal primary amine for conjugation chemistry.
High purity (99.9% by GC) suitable for research applications.
Molecular weight 119.16 and formula C5H13NO2.
Available in small lab quantities, e.g., 500 MG.
Recommended storage: 4°C, protect from light; in solvent store at -80°C for long-term.

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3,431

Medchemexpress LLC Romaciclib monohydrochloride | 2443816-41-7 | 99.29% | 450.60 | 10 MG

Romaciclib monohydrochloride (SEL120-34A monohydrochloride) is an ATP-competitive and selective inhibitor of Cyclin-Dependent Kinase 8 (CDK8). It demonstrates potent inhibitory activity against the kinase complexes of CDK8/CycC and CDK19/CycC, with IC50 values of 4.4 nM and 10.4 nM, respectively, and a Kd of 3 nM for CDK8. While it weakly inhibits CDK9, it shows no significant activity against other CDKs such as CDK1, 2, 4, 6, 5, and 7. The compound effectively inhibits the phosphorylation of STAT1 S727 and STAT5 S726 and has demonstrated anti-tumor activity.

Selective inhibition of specific cyclin-dependent kinases.
ATP-competitive mechanism of action.
Impacts key signaling pathways by inhibiting STAT1 S727 and STAT5 S726 phosphorylation.
Demonstrated efficacy in anti-tumor applications.

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3,432

Ambeed tertButyl 1S 3S 3aminocyclop

tert-Butyl ((1S,3S)-3-aminocyclopentyl)carbamate, 645400-44-8, 95%

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3,433

Ambeed Pyrazine2carbaldehyde

Pyrazine-2-carbaldehyde, 5780-66-5, 95%

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3,434

Ambeed 1R 2S 1Amino2 3dihydro1Hinden

(1R,2S)-1-Amino-2,3-dihydro-1H-inden-2-ol, 136030-00-7, 98%

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3,435

Ambeed R 5 S 1 2Dihydroxyethyl 3 4d

(R)-5-((S)-1,2-Dihydroxyethyl)-3,4-dihydroxyfuran-2(5H)-one, 50-81-7, 98%

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Quinolines and derivatives

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Medchemexpress LLC Revumenib | 2169919-21-3 | 99.99% | 630.82 | 200 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Peg-bis-amine (MW 2000) | 24991-53-5 | 99.4% | (C2H4O)nC4H12N2O | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC M-PEG12-AMINE 10MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC MPEG-amine (MW 20000) | 80506-64-5 | 98.0% | (C2H4O)nC3H9NO | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC 2,5,8,11,14,17,20,23,26-nonaoxaoctacosan-28-amine | 211859-73-3 | MFCD16619283 | 97.0% | 427.53 | C19H41NO9 | 250 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Apexbio Technology LLC APEXBIO TECHNOLOGY LLC Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Ethanamine, 2-(2-methoxyethoxy)- | 31576-51-9 | 99.9% | 119.16 | C5H13NO2 | 500 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More

Medchemexpress LLC Romaciclib monohydrochloride | 2443816-41-7 | 99.29% | 450.60 | 10 MG Small and Specialty Supplier PartnerSmall and/or specialty supplier based on Federal laws and SBA requirements.Learn More